Clinical Neuropathology teaching case 4-2015: Heterogenous brain pathologies temporally and spatially coinciding in limbic regions

Co-occurrence of neurodegenerative proteinopathies is increasingly recognized to be a frequent event in the brains of symptomatic and asymptomatic elderly individuals [1]. Prion diseases are rapidly progressive neurodegenerative conditions, which may pose differential diagnostic challenges. Co-occurence of diverse pathologies in prion disease is rarely reported, although occasionally unusual combinations may be detected [2]. We present here a case in which hetereogenous brain pathologies temporally and spatially coincided in medial temporal regions.